Author

A. Subramaniam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Organism:E. coli· 1

Frequent Co-Authors

A. Backstrom· 1 shared A. Garcia Garcia· 1 shared A. Krishnan· 1 shared B. Yiguang· 1 shared C. Sanden· 1 shared D. B. Raina· 1 shared D. H. Gil· 1 shared D. Zacharaki· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Backstrom

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SIRPα controls CD47-dependent platelet clearance in mice and humans

M. Shoham, Y. Y. Yiu, P. Hansen, A. Subramaniam, M. Broberg, E. Gars, T. Raveh, FinnGen, I. L. Weissman, N. Sinnott-Armstrong, A. Krishnan, H. Ollila, M. C. Tal

This study shows that the CD47-SIRP axis regulates platelet homeostasis and that blocking this interaction affects platelet levels in mice and humans.

bioRxiv · Dec 9, 2023 · PreprintImmunology

Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

S. Prithiviraj, A. Garcia Garcia, K. Linderfalk, B. Yiguang, S. Ferveur, L. N. Falck, A. Subramaniam, S. Mohlin, D. H. Gil, S. J. Dupard, D. Zacharaki, D. B. Raina, P. E. Bourgine

This study uses CRISPR/Cas9 to edit human mesenchymal stem cells to produce engineered extracellular matrices with modified VEGF and RUNX2 expression, showing altered osteogenic properties.

bioRxiv · Jul 28, 2023Bioengineering

Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations

A. Subramaniam, C. Sanden, L. Moura-Castro, K. Zemaitis, L. Schmiderer, A. Backstrom, E. Arvidsson, S. Hultmark, N. Miharada, K. Paulsson, T. Fioretos, J. Larsson

This study demonstrates that partial STAG1 perturbation selectively kills STAG2-mutated AML cells while sparing normal HSCs, showing synthetic lethality in xenograft models.

bioRxiv · Feb 18, 2022Cancer Biology

Detoxification of endogenous serine prevents cell lysis upon glucose depletion in bacteria

M. A. Kriner, A. Subramaniam

The paper shows that E. coli detoxifies endogenous serine to prevent lysis during glucose depletion by exporting serine via SdaC, revealing a protective role for serine export over deamination.

bioRxiv · Jun 11, 2018Microbiology