Towards understanding cancer stem cell heterogeneity in the tumor microenvironment
F. Bocci, L. Gearhart-Serna, M. Boareto, M. Ribeiro, E. Ben-Jacob, G. R. Devi, H. Levine, J. N. Onuchic, M. K. Jolly
This paper develops a computational-experimental framework to explain the spatial heterogeneity of cancer stem cells in the tumor microenvironment, showing that Notch-JAG1 signaling and inflammatory cytokines drive CSC distribution and stemness.
Proceedings of the National Academy of Sciences · Dec 26, 2018Peer-reviewedCancer Biology