S. A. Mani

Integrated single-cell functional and molecular profiling of extracellular vesicle secretion in metastatic breast cancer

The paper identifies a four-gene signature associated with EV secretion in breast cancer and links it to poor prognosis and immune evasion.

Acquisition of cancer stem cell properties during EMT requires cell division

This study shows that cancer cells acquire stem cell properties during EMT through cell division, not the mesenchymal program, and highlights the importance of EMT-induced stemness markers for clinical prediction.

Functional single-cell profiling identifies that exosomes are associated with increased immune cell infiltration in non-metastatic breast cancer

The paper develops a single-cell technique to profile exosome secretion in breast cancer cells and finds that non-metastatic cells secrete more exosomes, which correlates with better prognosis and immune infiltration.

A possible role for epigenetic feedback regulation in the dynamics of the Epithelial-Mesenchymal Transition (EMT)

This paper investigates how epigenetic feedback affects EMT dynamics by integrating a feedback term into a computational model and supporting it with experimental data showing prolonged TGFβ exposure impairs reversion to the epithelial state.

Distinguishing Mechanisms Underlying EMT Tristability

The paper uses experimental and theoretical approaches to evaluate two models of EMT dynamics, finding experimental evidence supporting the ternary chimera switch model over the cascading bistable switches model.