Author

E. C. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 2 Biophysics· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:deep learning· 3 Assay:protein structure· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

D. Baker· 5 shared N. P. King· 4 shared A. Khmelinskaia· 3 shared A. J. Borst· 2 shared A. K. Bera· 2 shared A. Kang· 2 shared B. Sankaran· 2 shared J. Dauparas· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersBiochemistry

D. Baker

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Rapid and automated design of two-component protein nanomaterials using ProteinMPNN

R. J. de Haas, N. Brunette, A. Goodson, J. Dauparas, S. Y. Yi, E. C. Yang, Q. Dowling, H. Nguyen, A. Kang, A. K. Bera, B. Sankaran, R. de Vries, D. Baker, N. P. King

This study benchmarks ProteinMPNN against Rosetta in designing two-component protein nanomaterials, showing comparable success with significantly reduced computation and no manual refinement.

bioRxiv · Aug 4, 2023Biochemistry

Blueprinting expandable nanomaterials with standardized protein building blocks

T. F. Huddy, Y. Hsia, R. D. Kibler, J. Xu, N. Bethel, D. Nagarajan, R. Redler, P. J. Y. Leung, A. Courbet, E. C. Yang, A. K. Bera, N. Coudray, S. J. Calise, F. A. Davila-Hernandez, C. Weidle, , D. Baker

This paper introduces standardized protein building blocks and geometric design principles to create expandable protein nanomaterials, validated through X-ray crystallography and electron microscopy.

bioRxiv · Jun 9, 2023Biochemistry

Computational design of non-porous, pH-responsive antibody nanoparticles

E. C. Yang, R. Divine, M. C. Miranda, A. J. Borst, W. Sheffler, J. Z. Zhang, J. Decarreau, A. Sarajovi, M. Abedi, N. Goldbach, M. Ahlrichs, C. Dobbins, A. Hand, S. Cheng, M. Lamb, , D. Baker

This paper designs pH-responsive antibody nanoparticles with three distinct protein components that disassemble at tunable pH levels, enabling targeted delivery of biologics.

bioRxiv · Apr 17, 2023Bioengineering

Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock

W. Sheffler, E. C. Yang, Q. Dowling, Y. Hsia, C. N. Fries, J. Stanislaw, M. Langowski, M. Brandys, A. Khmelinskaia, N. P. King, D. Baker

RPXDock enables fast, flexible protein docking for symmetric architectures, supporting diverse applications in nanomaterial design.

bioRxiv · Oct 25, 2022Bioengineering

Increasing computational protein design literacy through cohort-based learning for undergraduate students

E. C. Yang, R. Divine, C. S. Kang, S. Chan, E. Arenas, Z. Subol, P. Tinker, H. Manninen, A. Feichtenbiner, T. Mustafa, J. Hallowell, I. Orr, H. Haddox, B. Koepnick, J. O'Connor, , N. P. King

This paper describes a remote cohort-based curriculum for undergraduate students to learn computational protein design, enhancing their research skills and connecting them with the lab.

bioRxiv · May 24, 2022Scientific Communication & Education

The propofol binding sites of prokaryotic voltage-gated sodium channels

E. C. Yang, W. Bu, A. Suma, V. Carnevale, K. Grasty, P. Loll, K. Woll, N. Bhanu, B. A. Garcia, R. G. Eckenhoff, M. Covarrubias

This study identifies conserved propofol binding sites in prokaryotic voltage-gated sodium channels and shows how conformational changes at these sites mediate propofol's effects on channel function.

bioRxiv · Oct 28, 2020 · PreprintBiophysics