EHMT2/G9a-Inhibition Reprograms Cancer-Associated Fibroblasts (CAFs) to a More Differentiated, Less Proliferative and Invasive State
N. C. Wu, R. Quevedo, M. Nurse, K. Hezaveh, H. Liu, F. Sun, J. Muffat, Y. Sun, C. A. Simmons, T. L. McGaha, P. Prinos, C. H. Arrowsmith, L. Ailles, E. D'Arcangelo, A. P. McGuigan
This study identifies EHMT2 as a key regulator of CAF hyperproliferation and pro-invasive behavior, showing its inhibition reprograms CAFs to a less aggressive state.
bioRxiv · Jul 17, 2023 · PreprintCancer Biology