C. A. Simmons

Adverse structural and mechanical remodelling of main pulmonary artery in experimental pulmonary arterial hypertension is associated with impaired right ventricle-pulmonary artery coupling and function

This study examines structural and mechanical changes in the main pulmonary artery in pulmonary arterial hypertension and links them to impaired right ventricular function and coupling.

A microfluidic platform with integrated porous membrane cell-substrate impedance spectroscopy (PM-ECIS) for biological barrier assessment

This paper introduces a microfluidic platform with PM-ECIS for assessing biological barriers, showing improved performance over traditional TEER methods in the presence of biomaterials and under flow conditions.

Characterization of pediatric porcine pulmonary valves as a model for tissue engineered heart valves

This study characterizes the mechanical, ECM, and cellular properties of pediatric porcine pulmonary valves to inform the design of biomimetic tissue-engineered heart valves.

EHMT2/G9a-Inhibition Reprograms Cancer-Associated Fibroblasts (CAFs) to a More Differentiated, Less Proliferative and Invasive State

This study identifies EHMT2 as a key regulator of CAF hyperproliferation and pro-invasive behavior, showing its inhibition reprograms CAFs to a less aggressive state.

Sensitivity and validation of porous membrane electrical cell substrate impedance spectroscopy (PM-ECIS) for measuring endothelial barrier properties

This study evaluates PM-ECIS sensitivity to electrode size and its correlation with TEER, showing it can assess endothelial barrier properties non-invasively.

Porous membrane electrical cell-substrate impedance spectroscopy for versatile assessment of biological barriers in vitro

This paper introduces PM-ECIS, a cost-effective method for real-time, sensitive measurement of barrier function in porous membrane cell culture models.

Advanced physiological maturation of iPSC-derived human cardiomyocytes using an algorithm-directed optimization of defined media components

This study develops a novel medium for iPSC-derived cardiomyocytes using differential evolution to enhance maturation, validated through multiomic analysis.

High-frequency quantitative ultrasound to assess the acoustic properties of engineeredtissues in vitro

This paper uses high-frequency ultrasound to accurately measure acoustic properties of engineered tissues, showing that acoustic attenuation correlates with cell concentration.

Non-invasive quantification of contractile dynamics in cardiac cells, spheroids and organs-on-a-chip using high frequency ultrasound

This paper develops a high-frequency ultrasound technique to non-invasively measure contractile dynamics in cardiac cells, spheroids, and organs-on-a-chip, showing its ability to quantify beat rate, rhythm, and force with high temporal resolution.

Vascular tropism models of blood-borne microbial dissemination

This study investigates how B. burgdorferi strains interact with different vascular tissues and predicts their in vivo dissemination patterns based on vascular interaction properties.

Combinatorial Screen of Dynamic Mechanical Stimuli for Predictive Control of MSC Mechano-Responsiveness

The paper systematically investigates dynamic mechanical stimulation protocols for mesenchymal stromal cells to optimize matrix production and myofibrogenesis in 3D hydrogels.

Long-term functional culture and in vitro manipulation of adult mouse cardiomyocytes

This study develops methods to culture adult mouse cardiomyocytes long-term, maintaining their structure and function for in vitro experiments and genetic manipulations.