Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway
M. E. Deerhake, K. Danzaki, M. Inoue, E. D. Cardakli, T. Nonaka, N. Aggarwal, W. E. Barclay, R. R. Ji, M. L. Shinohara
This study shows Dectin-1 protects against CNS autoimmunity through a non-canonical pathway independent of Card9, promoting neuroprotective molecules like Osm in myeloid cells and reducing EAE severity via astrocytic OsmR signaling.
bioRxiv · May 6, 2020 · PreprintImmunology