This study develops a rat model of cirrhosis-induced hepatocellular carcinoma using thioacetamide, showing fibrosis, altered liver architecture, and increased AFP levels.

bioRxiv · Apr 18, 2024Pathology

Heat-inactivated mycobacteria activate the Toll-like receptor 2 and 4 pathways in the zebrafish model of tuberculosis

E. Ferreras Colino, M. Contreras, M. A. Risalde, I. Sevilla, E. Delgado, L. Dominguez, C. Gortazar, J. de la Fuente

The paper investigates the immune response to heat-inactivated mycobacteria in zebrafish, finding increased TLR2 and TLR4 gene expression but no reduction in mycobacterial burden.

bioRxiv · Mar 31, 2023Immunology

A spatial atlas of Wnt and Frizzled receptor expression in adult mouse liver

J. Gayden, S. Hu, P. N. Joseph, E. Delgado, S. Liu, A. Bell, S. Puig, S. P. Monga, Z. Freyberg

The paper maps the spatial expression of Wnt and Frizzled receptors in adult mouse liver, revealing zonation patterns and cell-type-specific expression.

bioRxiv · Sep 23, 2022 · PreprintCell Biology

Identification of CRF66_BF, a new HIV-1 circulating recombinant form of South American origin

J. Bacque, E. Delgado, S. Benito, M. Moreno-Lorenzo, V. Montero, H. Gil, M. Sanchez, M. C. Nieto-Toboso, J. Munoz, M. Z. Zubero-Sulibarria, E. Ugalde, E. Garcia-Bodas, J. E. Canada, J. del Romero, C. Rodriguez, , M. M. Thomson

The paper identifies CRF66_BF, a new HIV-1 circulating recombinant form of South American origin, distinct from CRF12_BF and prevalent in Paraguay.

bioRxiv · Sep 14, 2021Microbiology