M. Contreras

Cholinergic modulation engages a CHRM1-IL-17 neuroimmune axis to promote diabetic wound repair

The paper identifies a CHRM1-IL-17 neuroimmune axis that promotes diabetic wound healing through cholinergic modulation and local AChE inhibition.

Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection

The paper identifies TBC1D24 and SV2B as host factors required for antibody-dependent enhancement of dengue virus infection, beyond the role of FcgR.

How individual P. aeruginosa cells with diverse stator distributions collectively form a heterogeneous macroscopic swarming population

The paper shows that P. aeruginosa cells with different stator distributions create a heterogeneous swarming population through dynamic stator recruitment and motor intermittency.

Extracellular vesicles from preeclampsia disrupt the blood-brain barrier via reduced claudin-5: potential role of vascular endothelial growth factor

This study shows that extracellular vesicles from preeclampsia and hypoxic placentae reduce claudin-5 in the blood-brain barrier, potentially via VEGF, leading to BBB disruption and neurological deficits.

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses

The paper uses single-cell transcriptomics to identify new broadly neutralizing antibodies against flaviviruses, including an IgA1 isotype with unique neutralizing properties.

The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodies

This study identifies how single mutations in Zika virus envelope protein affect neutralization by broadly and narrowly specific antibodies, finding that broad antibodies are harder to escape.

Defining the impact of flavivirus envelope protein glycosylation on sensitivity to broadly neutralizing antibodies

This paper investigates how glycosylation of flavivirus envelope proteins affects neutralization by broadly neutralizing antibodies, finding that glycosylation modulates antibody potency in unexpected ways.

Heat-inactivated mycobacteria activate the Toll-like receptor 2 and 4 pathways in the zebrafish model of tuberculosis

The paper investigates the immune response to heat-inactivated mycobacteria in zebrafish, finding increased TLR2 and TLR4 gene expression but no reduction in mycobacterial burden.

Systemic effects of melanoma-secreted MIDKINE in the inhibition of dendritic cell differentiation and function

This study identifies MIDKINE as a factor secreted by melanomas that inhibits dendritic cell differentiation and function, contributing to immune resistance in melanoma.

A Machine Learning Framework to Predict Subcellular Morphology of Endothelial Cells for Digital Twin Generation

This paper develops a machine learning framework to predict 3D subcellular morphology of endothelial cells and generates digital twins with high accuracy.

Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes.

This paper identifies PF-477736 as a selective cytotoxic compound for LIMD1-deficient NSCLC cells and xenograft models, offering a potential targeted therapy for this understudied cancer subtype.

Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease

This study identifies bacterial biomarkers for distinguishing eubiosis from dysbiosis in IBD patients with high diagnostic accuracy.

The antibody response to the glycan α-Gal correlates with COVID-19 disease symptoms

This study examines the correlation between anti-α-Gal antibody levels and COVID-19 disease severity in patients compared to healthy controls.

An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species

The paper identifies a conserved N-terminal motif in plant NLR immune receptors and shows its functional conservation across species.