Author

E. E. de Souza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Assay:proteomics· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

A. F. dos Santos· 1 shared A. Luana C Barra· 1 shared B. Alves Franca· 1 shared C. B. Angeli· 1 shared C. R. F. Marinho· 1 shared C. Schmidt· 1 shared C. Wrenger· 1 shared D. B. Araujo· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. F. dos Santos

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design

V. Srinivasan, H. Brognaro, P. R. Prabhu, E. E. de Souza, S. Guenther, P. Y. A. Reinke, T. J. Lane, H. Ginn, H. Han, W. Ewert, J. Sprenger, F. H. M. Koua, S. Falke, N. Werner, H. Andaleeb, , P

This study identifies three natural compounds that inhibit SARS-CoV-2 PLpro by binding to the ISG15/Ub-S2 allosteric site, showing antiviral activity and potential for drug design.

Communications Biology · Aug 11, 2022Peer-reviewedBiochemistry

SARS-CoV-2 activates ER stress and Unfolded protein response

L. Rosa-Fernandes, L. C. Lazari, J. Macedo-da-Silvia, V. d. M. Gomes, R. R. G. Machado, A. F. dos Santos, D. B. Araujo, J. V. P. Coutinho, G. S. Arini, C. B. Angeli, E. E. de Souza, C. Wrenger, C. R. F. Marinho, D. B. L. Oliveira, E. L. Durigon, , G. Palmisano

This study shows SARS-CoV-2 activates ER stress and UPR pathways in infected cells, which are essential for viral replication and may be targets for antiviral drugs.

bioRxiv · Jun 21, 2021 · PreprintBiochemistry