Author

S. Falke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 3 Assay:structural biology· 3 Organism:virus· 3 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Lieske· 4 shared P. Y. A. Reinke· 4 shared C. Ehrt· 3 shared D. Oberthuer· 3 shared F. TrostiD· 3 shared H. Andaleeb· 3 shared H. Ginn· 3 shared K. Lorenzen· 3 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

J. Lieske

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Author profile →

6 papers

Recent·Most cited

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

V. Kremling, S. Falke, Y. Fernandez-Garcia, C. Ehrt, A. Kiene, B. Klopprogge, T. E. S. Scheer, F. Barthels, P. Middendorf, S. Kuehn, S. Guenther, M. Rarey, H. N. Chapman, D. Oberthuer, J. Sprenger

The paper identifies ligands binding to the SARS-CoV-2 nsp10-16 complex using X-ray crystallography and reports their structures, providing insights for drug discovery.

bioRxiv · Mar 13, 2024 · PreprintBiochemistry

Structural elucidation and antiviral activity of cathepsin L inhibitors with carbonyl and epoxide warheads

S. Falke, J. Lieske, A. Herrmann, J. Loboda, S. Gunther, P. Y. A. Reinke, W. Ewert, K. Karnicar, A. Usenik, N. Lindic, A. Sekirnik, H. Tsuge, V. Turk, H. N. Chapman, W. Hinrichs, , A. Meents

The paper presents crystal structures of cathepsin L inhibitors and evaluates their antiviral activity against SARS-CoV-2.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design

V. Srinivasan, H. Brognaro, P. R. Prabhu, E. E. de Souza, S. Guenther, P. Y. A. Reinke, T. J. Lane, H. Ginn, H. Han, W. Ewert, J. Sprenger, F. H. M. Koua, S. Falke, N. Werner, H. Andaleeb, , P

This study identifies three natural compounds that inhibit SARS-CoV-2 PLpro by binding to the ISG15/Ub-S2 allosteric site, showing antiviral activity and potential for drug design.

Communications Biology · Aug 11, 2022Peer-reviewedBiochemistry

Inhibition of SARS-CoV-2 main protease by allosteric drug-binding

S. Guenther, P. Y. A. Reinke, Y. Fernandez-Garcia, J. Lieske, T. J. Lane, H. Ginn, F. Koua, C. Ehrt, W. Ewert, D. Oberthuer, O. Yefanov, S. Meier, K. Lorenzen, B. Krichel, J. Kopicki, , Schwi

The paper identifies 37 compounds binding to SARS-CoV-2 main protease through X-ray crystallography, with five non-peptidic compounds showing antiviral activity in cell-based assays.

bioRxiv · Nov 12, 2020Biophysics

Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease

S. Günther, P. Y. A. Reinke, D. Oberthuer, O. Yefanov, H. Ginn, S. Meier, T. J. Lane, K. Lorenzen, L. Gelisio, W. Brehm, I. Dunkel, M. Domaracky, S. Saouane, J. Lieske, C. Ehrt, , G

The paper presents the crystal structure of SARS-CoV-2 main protease covalently bound to a metabolite of HEAT, revealing a pro-drug mechanism and potential for non-peptidic inhibitors.

bioRxiv · May 2, 2020 · PreprintBiophysics

Processing of the SARS-CoV pp1a/ab nsp7-10 region

B. Krichel, S. Falke, R. Hilgenfeld, L. Redecke, C. Uetrecht

The paper uses native mass spectrometry to analyze SARS-CoV polyprotein processing, revealing cleavage order and protein interactions in the nsp7-10 region.

bioRxiv · Dec 4, 2019Biophysics