Author

L. Rosa-Fernandes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:proteomics· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

G. Palmisano· 6 shared J. Macedo-da-Silva· 3 shared V. d. M. Gomes· 3 shared C. B. Angeli· 2 shared C. R. F. Marinho· 2 shared C. Wrenger· 2 shared E. L. Durigon· 2 shared G. S. de Oliveira· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersBiochemistry

G. Palmisano

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

ATE1 activates ER-stress and UPR pathways in glioblastoma

J. Macedo-da-Silva, S. M. Oba-Shinjo, L. Rosa-Fernandes, R. d. S. Soares, A. M. Lerario, I. F. Moretti, T. d. S. Laurentino, R. C. Cintra, S. K. N. Marie, G. Palmisano

This study investigates the role of ATE1-mediated N-terminal arginylation in glioblastoma, finding it activates ER-stress and UPR pathways, promotes autophagy, and supports tumor growth.

bioRxiv · Sep 25, 2023 · PreprintCancer Biology

Protein arginylation is regulated during SARS-CoV-2 infection

J. Macedo-da-Silva, L. Rosa-Fernandes, V. d. M. Gomes, V. F. Santiago, C. M. S. Molnar, B. R. Barboza, E. E. de Sousa, E. L. Durigon, C. R. F. Marinho, C. Wrenger, S. K. N. Marie, G. Palmisano

This study investigates how protein arginylation changes during SARS-CoV-2 infection and shows that ATE1 expression and arginylated protein levels are regulated in infected cells.

bioRxiv · Nov 2, 2021Cell Biology

SARS-CoV-2 activates ER stress and Unfolded protein response

L. Rosa-Fernandes, L. C. Lazari, J. Macedo-da-Silvia, V. d. M. Gomes, R. R. G. Machado, A. F. dos Santos, D. B. Araujo, J. V. P. Coutinho, G. S. Arini, C. B. Angeli, E. E. de Souza, C. Wrenger, C. R. F. Marinho, D. B. L. Oliveira, E. L. Durigon, , G. Palmisano

This study shows SARS-CoV-2 activates ER stress and UPR pathways in infected cells, which are essential for viral replication and may be targets for antiviral drugs.

bioRxiv · Jun 21, 2021 · PreprintBiochemistry

Systems-wide analysis of glycoprotein conformational changes by limited deglycosylation assay

S. N. Mule, L. Rosa-Fernandes, J. V. P. Coutinho, V. D. M. Gomes, J. Macedo-da-Silva, V. F. Santiago, D. O. Quina, G. S. de Oliveira, M. Thaysen-Andersen, M. R. Larsen, L. Labriola, G. Palmisano

The paper introduces a new method called LDA to analyze glycoprotein conformational changes on a systems-wide scale and demonstrates its application in detecting structural changes under ER stress.

bioRxiv · Jun 4, 2021Biochemistry

New insights into Trypanosoma cruzi evolution and genotyping based on system-wide protein expression profiles (PhyloQuant)

S. Ngao Mule, A. Guillherme da Costa Martins, L. Rosa-Fernandes, G. Santos de Oliveira, C. M. Rodrigues, D. Quina, G. E. Rosein, M. M. G. Teixeira, G. Palmisano

This study introduces a proteomics-based method called phyloquant to classify Trypanosoma cruzi strains into genetic subdivisions and infer evolutionary relationships using protein expression profiles.

bioRxiv · Feb 21, 2020 · PreprintEvolutionary Biology

CImP: Cellular Imprinting Proteomics applied to ocular disorders elicited by Congenital Zika virus Syndrome

L. Rosa-Fernandes, R. H. Barbosa, M. L. B. dos Santos, C. B. Angeli, T. P. Silva, R. C. N. Melo, G. S. de Oliveira, B. Lemos, M. R. Larsen, C. A. Cardoso, G. Palmisano

The paper introduces CImP, a proteomics method for analyzing ocular surface cells in infants with and without Congenital Zika Syndrome, identifying molecular changes linked to ZIKV exposure.

bioRxiv · May 24, 2019 · PreprintBiochemistry