Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo
E. G. Estell, P. T. Le, Y. Vegting, H. Kim, R. Baron, B. Spiegelman, C. J. Rosen
This study shows irisin directly promotes osteoclast differentiation and bone resorption in vitro and in vivo, suggesting it regulates bone remodeling beyond its effects on osteoblasts.
bioRxiv · May 9, 2020Cell Biology