P. T. Le

PTH regulates osteogenesis and suppresses adipogenesis through Zfp 467 in a feed-forward, cyclic AMP-dependent manner

This study shows that PTH regulates bone formation by suppressing Zfp467 through cyclic AMP/PKA pathway, enhancing Pth1r transcription and osteogenesis.

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

This study shows irisin directly promotes osteoclast differentiation and bone resorption in vitro and in vivo, suggesting it regulates bone remodeling beyond its effects on osteoblasts.