C. J. Rosen

PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation

This paper shows that PPARG in osteocytes regulates bioenergetics and systemic energy metabolism in mice, independent of sclerostin levels, with sex-specific effects on mitochondrial function and insulin signaling.

Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner

This study shows that irisin deletion affects murine osteocyte function differently in males and females, with protection in females under calcium deficiency and increased bone loss in males.

Atlas of Fshr Expression from Novel Reporter Mice

This paper develops Fshr-ZsGreen knockin reporter mice to study FSHR expression in vivo, revealing novel extragonadal expression patterns and expanding the known physiological roles of the FSH-FSHR pathway.

Development and Biophysical Characterization of a Humanized FSH-Blocking Monoclonal Antibody Therapeutic Formulated at an Ultra-High Concentration

This paper develops a stable, high-concentration formulation of a humanized FSH-blocking antibody and validates its physicochemical and thermal stability.

PTH regulates osteogenesis and suppresses adipogenesis through Zfp 467 in a feed-forward, cyclic AMP-dependent manner

This study shows that PTH regulates bone formation by suppressing Zfp467 through cyclic AMP/PKA pathway, enhancing Pth1r transcription and osteogenesis.

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

This study creates a single-cell atlas of the bone microenvironment in healthy and inflammatory states, identifying key MSC subclusters and their biomarkers in apical periodontitis.

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

This study shows that BMAd lipolysis is essential for maintaining myelopoiesis, bone mass, and bone regeneration during energy deficits.

A Single Multipurpose FSH-Blocking Therapeutic for Osteoporosis and Obesity

This paper develops and tests a first-in-class FSH-blocking antibody, MS-Hu6, showing efficacy in preventing obesity and osteoporosis in mice and safety in monkeys.

Maf1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

This study shows Maf1 regulates bone mass by modulating RNA polymerase III transcription, with both loss and gain of function leading to high bone mass, but through distinct mechanisms.

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

The paper shows that YKL-05-099, which inhibits SIKs and CSF1R, increases bone formation without increasing bone resorption in mice.

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

This study shows irisin directly promotes osteoclast differentiation and bone resorption in vitro and in vivo, suggesting it regulates bone remodeling beyond its effects on osteoblasts.

PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity

This study shows that PHOSPHO1 deficiency improves glucose homeostasis and protects against obesity and diabetes without altering osteocalcin levels.