A. Desai

Phospho-KNL-1 recognition by a TPR domain targets the BUB-1/BUB-3 complex to C. elegans kinetochores

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses

This study identifies cyclin B3 as the key driver of rapid mitoses in early C. elegans embryos, showing it enables faster cell division compared to cyclin B1 and B2.

Regulation of lipolysis by 14-3-3 proteins on human adipocyte lipid droplets.

This study identifies 14-3-3 proteins as regulators of lipolysis in human adipocytes by analyzing the PLIN1 interactome using proximity labeling.

Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore

This study shows that kinetochore dynein can biorient chromosomes and remodel the outer kinetochore, but not congress them, during mitosis.

Control of cell proliferation by memories of mitosis

The paper shows that mitotic duration memories control cell proliferation through a p53-based pathway, halting proliferation after extended or successive mitoses.

PLK-1 tethered on BUB-1 directs CDC-20 kinetochore recruitment to ensure timelyembryonic mitoses

This study shows that PLK-1 tethered on BUB-1 promotes CDC-20 recruitment to kinetochores, ensuring timely mitosis in C. elegans embryos through phosphoregulation.

Nuclear-enriched protein phosphatase 4 ensures outer kinetochore assemblyprior to nuclear dissolution

The paper shows that PP4 ensures outer kinetochore assembly before nuclear envelope breakdown, which is critical for proper chromosome segregation.

Sex-specific T cell exhaustion drives differential immune responses in glioblastoma

This study shows male T cells are more exhausted in glioblastoma, leading to worse outcomes and better response to anti-PD1 treatment compared to females.

Effects of tumor mutation burden on the antigen presentation pathway

The paper examines how tumor mutation burden affects antigen presentation pathway genes and finds that APG mutations are linked to improved progression-free survival with PD-1 inhibitors.

The N-terminal Tail of C. elegans CENP-A Interacts with KNL-2 and is Essential for Centromeric Chromatin Assembly

This study identifies the N-terminal tail of C. elegans CENP-A as essential for centromeric chromatin assembly through its interaction with KNL-2, compensating for the absence of Scm3/HJURP.

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome

This study shows that Polo-like kinase 1 directly controls microtubule-nucleating sites on centrosomes, independent of centrosome size, and is critical for spindle assembly.

Multiple human adipocyte subtypes and mechanisms of their development

The paper identifies four human adipocyte subtypes through single-cell transcriptomics and describes their developmental mechanisms and functional roles.

Ancestral Roles of the Fam20C Family of Secreted Protein Kinases Revealed by Functional Analysis in C. elegans

This study identifies FAMK-1, the C. elegans ortholog of Fam20C, as essential for fertility, embryogenesis, and development through its role in maintaining cellular partitions and responding to mechanical strain.

A positive feedback-based mechanism for constriction rate acceleration during cytokinesis in C. elegans

The paper investigates cytokinesis in C. elegans embryos, showing that positive feedback between myosin and cortical flow accelerates ring constriction rate as the ring shrinks.

Generation of functional human adipose tissue in mice from primed progenitor cells

The paper shows that priming mesenchymal progenitor cells in vitro leads to the formation of functional human adipose tissue in mice, improving vascularization and reducing cell death compared to unprimed grafts.

Deconvolution Of Subcellular Protrusion Heterogeneity And The Underlying Actin Regulator Dynamics From Live Cell Imaging

This paper introduces HACKS, a machine learning framework to analyze live cell imaging data and uncover subcellular protrusion heterogeneity and actin regulator dynamics.

CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia

This study shows CYK-4, but not ZEN-4, is required for oocyte cellularization in C. elegans germline syncytia through a C1-GAP module that targets it to intercellular bridges.