K. Oegema

Phospho-KNL-1 recognition by a TPR domain targets the BUB-1/BUB-3 complex to C. elegans kinetochores

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses

This study identifies cyclin B3 as the key driver of rapid mitoses in early C. elegans embryos, showing it enables faster cell division compared to cyclin B1 and B2.

Control of cell proliferation by memories of mitosis

The paper shows that mitotic duration memories control cell proliferation through a p53-based pathway, halting proliferation after extended or successive mitoses.

PLK-1 tethered on BUB-1 directs CDC-20 kinetochore recruitment to ensure timelyembryonic mitoses

This study shows that PLK-1 tethered on BUB-1 promotes CDC-20 recruitment to kinetochores, ensuring timely mitosis in C. elegans embryos through phosphoregulation.

The N-terminal Tail of C. elegans CENP-A Interacts with KNL-2 and is Essential for Centromeric Chromatin Assembly

This study identifies the N-terminal tail of C. elegans CENP-A as essential for centromeric chromatin assembly through its interaction with KNL-2, compensating for the absence of Scm3/HJURP.

Polo-like kinase 1 independently controls microtubule-nucleating capacity and size of the centrosome

This study shows that Polo-like kinase 1 directly controls microtubule-nucleating sites on centrosomes, independent of centrosome size, and is critical for spindle assembly.

Ancestral Roles of the Fam20C Family of Secreted Protein Kinases Revealed by Functional Analysis in C. elegans

This study identifies FAMK-1, the C. elegans ortholog of Fam20C, as essential for fertility, embryogenesis, and development through its role in maintaining cellular partitions and responding to mechanical strain.

A positive feedback-based mechanism for constriction rate acceleration during cytokinesis in C. elegans

The paper investigates cytokinesis in C. elegans embryos, showing that positive feedback between myosin and cortical flow accelerates ring constriction rate as the ring shrinks.

TPXL-1 Activates Aurora A to Clear Contractile Ring Components from the Polar Cortex During Cytokinesis

The paper identifies TPXL-1 as a factor that activates Aurora A kinase to remove contractile ring components from cell poles during cytokinesis.

CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia

This study shows CYK-4, but not ZEN-4, is required for oocyte cellularization in C. elegans germline syncytia through a C1-GAP module that targets it to intercellular bridges.