LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
C. Li, M. U. Syed, A. Nimbalkar, Y. Shen, C. Fraser, Z. Inde, X. Qin, J. Ouyang, J. Kreuzer, S. E. Clark, G. E. Kelley, E. Hensley, A. Oh, M. Walcott, R. Morris, , A. N. Hata
This study shows LKB1 suppresses JNK-dependent stress signaling in KRAS-mutant lung cancers, revealing a therapy-induced vulnerability that could improve KRAS-targeted therapies.
bioRxiv · Sep 29, 2022 · PreprintCancer Biology