Author

E. Hoogenboezem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 1

Frequent Co-Authors

C. Duvall· 2 shared J. Rosch· 2 shared A. Cavnar· 1 shared A. Sorets· 1 shared C. DeJulius· 1 shared D. L. Michell· 1 shared E. Lippmann· 1 shared J. Colazo· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

C. Duvall

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2 papers

Recent·Most cited

Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

E. Hoogenboezem, S. S. Patel, A. Cavnar, J. Lo, L. Babb, N. Francini, P. Patil, J. Colazo, D. L. Michell, V. Sanchez, J. McCune, J. Ma, C. DeJulius, L. Lee, J. Rosch, , C. Duvall

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

bioRxiv · Feb 14, 2023 · PreprintBioengineering

Albumin-binding Aptamer Chimeras for Improved siRNA Bioavailability

J. Rosch, E. Hoogenboezem, A. Sorets, C. Duvall, E. Lippmann

This study develops albumin-binding aptamer-siRNA chimeras to enhance siRNA bioavailability, showing improved stability, gene knockdown, and extended circulation in vivo.

bioRxiv · Apr 15, 2021Bioengineering