Author

J. McCune

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

A. Cavnar· 1 shared B. Aguilar· 1 shared B. Loera· 1 shared B. Tercan· 1 shared C. DeJulius· 1 shared C. Duvall· 1 shared D. L. Michell· 1 shared E. Hoogenboezem· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioengineering

A. Cavnar

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2 papers

Recent·Most cited

Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia

G. Qin, J. Dai, S. Chien, T. J. Martins, B. Loera, Q. Nguyen, M. L. Oakes, B. Tercan, B. Aguilar, L. Hagen, J. McCune, R. Gelinas, R. J. Monnat, I. Shmulevich, P. S. Becker

The paper identifies mutation patterns linked to drug sensitivity in AML using integrated computational and experimental analysis.

bioRxiv · May 24, 2023Cell Biology

Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

E. Hoogenboezem, S. S. Patel, A. Cavnar, J. Lo, L. Babb, N. Francini, P. Patil, J. Colazo, D. L. Michell, V. Sanchez, J. McCune, J. Ma, C. DeJulius, L. Lee, J. Rosch, , C. Duvall

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

bioRxiv · Feb 14, 2023 · PreprintBioengineering