Author

A. Sorets

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

C. Duvall· 2 shared E. Hoogenboezem· 2 shared E. Lippmann· 2 shared A. Abdulrahman· 1 shared A. Gravanis· 1 shared A. Kjar· 1 shared A. Ligocki· 1 shared A. Prusky· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

C. Duvall

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Author profile →

3 papers

Recent·Most cited

Lipid-siRNA conjugate accesses a perivascular transport mechanism and achieves widespread and durable knockdown in the central nervous system

A. Sorets, K. Schwensen, N. Francini, A. Kjar, A. Abdulrahman, A. Shostak, K. Katdare, K. Schoch, R. Cowell, J. Park, A. Ligocki, W. Ford, L. Ventura-Antunes, E. Hoogenboezem, A. Prusky, , E. Lippmann

This study develops a lipid-siRNA conjugate that uses perivascular transport to achieve long-lasting gene knockdown in the CNS without toxicity.

bioRxiv · Jun 9, 2024 · PreprintBioengineering

A Microengineered Brain-Chip to Model Neuroinflammation in Humans

I. Pediaditakis, K. R. Kodella, D. V. Manatakis, C. Y. Le, S. Barthakur, A. Sorets, A. Gravanis, L. Ewart, L. L. Rubin, E. S. Manolakos, C. D. Hinojosa, K. Karalis

The paper presents a human Brain-Chip that models neuroinflammation by recapitulating brain cell interactions and BBB function, showing improved complexity and clinical relevance compared to existing models.

bioRxiv · Mar 11, 2022Bioengineering

Albumin-binding Aptamer Chimeras for Improved siRNA Bioavailability

J. Rosch, E. Hoogenboezem, A. Sorets, C. Duvall, E. Lippmann

This study develops albumin-binding aptamer-siRNA chimeras to enhance siRNA bioavailability, showing improved stability, gene knockdown, and extended circulation in vivo.

bioRxiv · Apr 15, 2021Bioengineering