S. S. Patel

The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the antiviral innate immune response

Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

The N-terminal domain of the human mitochondrial helicase Twinkle has DNA binding activity crucial for supporting processive DNA synthesis by Polymerase γ

Yeast mtDNA transcription initiation in single nucleotide addition steps

This study reports cryo-EM structures of yeast mitochondrial RNA polymerase initiation complexes, revealing the stepwise process of transcription initiation and the role of structural changes in RNA synthesis.

RIG-I uses its intrinsically disordered CARDs-Helicase linker in RNA proofreading functions

This study identifies a proofreading mechanism in RIG-I that uses the CARDs-Helicase Linker to gate RNA specificity and stabilize interactions, preventing non-specific RNA engagement.

Indexable signal amplification for multiparametric imaging

The paper introduces tyramide-conjugated DNA barcodes for multiparametric imaging, enabling rapid antibody panel development without modifying primary antibodies.

Cryo-EM structures reveal transcription initiation steps by yeast mitochondrial RNA polymerase

The paper uses cryo-EM to reveal steps of transcription initiation by yeast mitochondrial RNA polymerase, including promoter melting, template alignment, and abortive synthesis mechanisms.

Auto-inhibitory regulation of DNA binding by the C-terminal tails of the mitochondrial transcription factors Mtf1 and TFB2M

This study identifies autoinhibitory mechanisms in Mtf1 and TFB2M where the C-tail region regulates DNA binding activity through intramolecular interactions, which are relieved by RNA polymerase interaction.

Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid Nanocarriers

This paper identifies Kupffer cell release of platelet activating factor (PAF) as a key driver of nanocarrier toxicity and shows that PAFR inhibition prevents dose-limiting toxicities in mice.

The Dynamic Landscape of Transcription Initiation in Yeast Mitochondria

This study investigates the conformational dynamics of yeast mitochondrial transcription initiation using single-molecule techniques, revealing dynamic transitions and backtracking behavior.

Neev, a novel long non-coding RNA, is expressed in chaetoblasts during regeneration of Eisenia fetida

The paper identifies a novel lncRNA, Neev, expressed in regenerating earthworm segments and proposes it functions as a miRNA sponge to regulate chitin synthesis during regeneration.

Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD+ and NADH by yeast and human mitochondrial RNA polymerase

The paper shows mitochondrial RNA polymerases in yeast and human cells efficiently cap RNA with NAD+ and NADH, linking metabolism to mitochondrial gene expression.

The Rate Of Evolution Of Postmating-Prezygotic Reproductive Isolation In Drosophila

The paper measures the rate of evolution of postmating-prezygotic reproductive isolation in Drosophila and finds it evolves faster than hybrid inviability but slower than premating isolation.