J. Rosch

Structural Optimization of siRNA Conjugates for Albumin Binding Achieves Effective MCL1-Targeted Cancer Therapy

This paper optimizes siRNA conjugates for albumin binding to enhance tumor delivery and efficacy in cancer therapy, achieving 80% MCL1 silencing and improved survival in breast cancer models.

Pneumococcal Evasion of Antibiotics via Metabolic Adaptation During Infection

This study shows that S. pneumoniae evades fluoroquinolone antibiotics through metabolic adaptation that reduces reactive oxygen species production, enabling tolerance and fitness restoration.

Albumin-binding Aptamer Chimeras for Improved siRNA Bioavailability

This study develops albumin-binding aptamer-siRNA chimeras to enhance siRNA bioavailability, showing improved stability, gene knockdown, and extended circulation in vivo.

Immunosuppression broadens evolutionary pathways to treatment failure during Acinetobacter baumannii pneumonia

This study shows that immunosuppression promotes antibiotic resistance evolution in Acinetobacter baumannii pneumonia by enabling persistence mutations that cause treatment failure without clinical resistance.

Dynamic pneumococcal genetic adaptations support bacterial growth and inflammation during coinfection with influenza

This study identifies bacterial genes critical for pneumococcal virulence and immune modulation during influenza coinfection using transposon mutagenesis and in vivo analysis.

Identification of colonisation and virulence determinants of Streptococcus pneumoniae via experimental evolution in mouse infection models

This study uses experimental evolution in mouse models to identify genetic factors affecting Streptococcus pneumoniae colonization and virulence.

Respiratory bacteria stabilize and promote airborne transmission of influenza A virus

This study shows that respiratory bacteria enhance the stability and transmission of influenza A virus through direct interactions.

Allergic inflammation hinders synergistic viral-bacterial co-infection in C57BL/6 mice

This study shows that allergic inflammation in mice reduces severity of viral-bacterial co-infection by altering the lung microbiome and immune response.

The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence