Increased core body temperature exacerbates defective protein prenylation in mouse avatars of mevalonate kinase deficiency
M. A. Munoz, O. P. Skinner, E. Masle-Farquhar, J. Jurczyluk, Y. Xiao, E. K. Fletcher, E. Kristianto, M. P. Hodson, S. I. O'Donoghue, S. Kaur, R. Brink, D. Zahra, E. K. Deenick, K. Perry, A. A. Robertson, , M. J. Rogers
This study shows that increased body temperature worsens protein prenylation defects in mouse models of mevalonate kinase deficiency, suggesting temperature as a trigger for inflammation.
bioRxiv · Feb 28, 2022 · PreprintPhysiology