Author

E. Le Cam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. Dupaigne· 3 shared J. Guirouilh-Barbat· 2 shared A. A. Muhammad· 1 shared A. Allouch· 1 shared A.-A. Muhammad· 1 shared A.-L. Soulet· 1 shared B. Lopez· 1 shared B. S. Lopez· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

P. Dupaigne

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Bacterial Replicative Helicase Loader DciA is a DNA Condenser.

S. Marsin, S. Jeannin, S. Baconnais, H. Walbott, G. Pehau-Arnaudet, M. Noiray, M. Aumont-Nicaise, E. G. Stender, C. Cargemel, R. Le Bars, E. Le Cam, S. Quevillon-Cheruel

This study shows that DciA forms DNA condensates through liquid-liquid phase separation, facilitating replication protein assembly near chromosomal DNA.

bioRxiv · Sep 8, 2023 · PreprintBiochemistry

Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from Streptococcus pneumoniae.

M. Hertzog, T. N. Perry, P. Dupaigne, S. Serres, V. Morales, A.-L. Soulet, J. Bell, E. Margeat, S. C. Kowalczykowski, E. Le Cam, R. Fronzes, P. Polard

This study characterizes the ATP-dependent assembly mechanism and cryoEM structure of RecA nucleofilaments from Streptococcus pneumoniae, revealing differences in ssDNA binding and HR activity compared to Escherichia coli.

bioRxiv · Jul 28, 2022 · PreprintMicrobiology

Human RAD52 stimulates the RAD51-mediated homology search

A. A. Muhammad, T. Peterlini, J. Guirouilh-Barbat, X. Veaute, D. Busso, B. Lopez, J.-Y. Masson, G. Mazon, E. Le Cam, P. Dupaigne

This study investigates the role of RAD52 in homologous recombination by analyzing its interaction with BRCA2 and RAD51 using electron microscopy and biochemistry.

bioRxiv · Jun 27, 2022Biochemistry

In vivo inactivation of RAD51-mediated homologous recombination leads to premature aging, but not to tumorigenesis

G. Matos-Rodrigues, V. Barroca, A.-A. Muhammad, A. Allouch, S. Koundrioukoff, D. Lewandowski, E. Despras, J. Guirouilh-Barbat, L. Frappart, P. Kannouche, P. Dupaigne, E. Le Cam, J.-L. Perfettini, P.-H. Romeo, M. Debatisse, , B. S. Lopez

This study shows that inactivating RAD51 in mice causes premature aging but not cancer, suggesting RAD51 is critical for progenitor cell homeostasis.

bioRxiv · Jan 17, 2022 · PreprintCancer Biology