Author

J. Guirouilh-Barbat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

E. Le Cam· 2 shared P. Dupaigne· 2 shared A. A. Muhammad· 1 shared A. Allouch· 1 shared A.-A. Muhammad· 1 shared B. Lopez· 1 shared B. S. Lopez· 1 shared C. Gelot· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

E. Le Cam

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

C. Gelot, M. T. Kovacs, S. Miron, E. Mylne, R. Ghouil, T. Popova, F. Dingli, D. Loew, J. Guirouilh-Barbat, E. Del Nery, S. Zinn-Justin, R. Ceccaldi

This study identifies Polθ as a key factor in repairing DNA double strand breaks during mitosis, showing that its phosphorylation by PLK1 enables this process and maintains genome integrity.

bioRxiv · Mar 17, 2023Cell Biology

Human RAD52 stimulates the RAD51-mediated homology search

A. A. Muhammad, T. Peterlini, J. Guirouilh-Barbat, X. Veaute, D. Busso, B. Lopez, J.-Y. Masson, G. Mazon, E. Le Cam, P. Dupaigne

This study investigates the role of RAD52 in homologous recombination by analyzing its interaction with BRCA2 and RAD51 using electron microscopy and biochemistry.

bioRxiv · Jun 27, 2022Biochemistry

In vivo inactivation of RAD51-mediated homologous recombination leads to premature aging, but not to tumorigenesis

G. Matos-Rodrigues, V. Barroca, A.-A. Muhammad, A. Allouch, S. Koundrioukoff, D. Lewandowski, E. Despras, J. Guirouilh-Barbat, L. Frappart, P. Kannouche, P. Dupaigne, E. Le Cam, J.-L. Perfettini, P.-H. Romeo, M. Debatisse, , B. S. Lopez

This study shows that inactivating RAD51 in mice causes premature aging but not cancer, suggesting RAD51 is critical for progenitor cell homeostasis.

bioRxiv · Jan 17, 2022 · PreprintCancer Biology