R. Sounier

Biased activation of the vasopressin V2 receptor probed by NMR, paramagnetic ligands, and molecular dynamics simulations

The paper uses NMR, molecular dynamics, and pharmacology to study conformational changes in the V2R receptor bound to different ligands, revealing a mechanism for Gs-biased agonism involving TM7 and TM3 interactions.

Structure of the vasopressin hormone-V2 receptor-β-arrestin1 ternary complex

The paper reports the cryo-EM structure of the V2 receptor-{beta}-arrestin1 complex, revealing structural variability in GPCR-arrestin interactions.

Mechanisms of GPCR hijacking by Staphylococcus aureus

This study investigates how Staphylococcus aureus leukotoxins HlgA and HlgB interact with ACKR1, altering its structure and function to aid bacterial growth and immune evasion.

Structure of the antidiuretic hormone vasopressin receptor signalling complex.

The paper reports the structure of the AVP-V2R-Gs complex using cryo-EM, revealing distinct conformations and a unique receptor-Gs interface that explains genetic disease variants.

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

The paper integrates NMR and cryo-EM to determine the atomic structure of a large enzyme complex, achieving high precision and accuracy beyond the limitations of each method individually.

Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy

The paper reports the crystal structure of human ACER3, revealing its intramembrane architecture and explaining Ca2+ and Zn2+ regulation of its enzymatic activity and dysfunction in leukodystrophy.