Author

E. Pohler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

I. Moraga· 4 shared A. Cozzani· 3 shared J. Piehler· 3 shared S. Mitra· 3 shared J. Martinez-Fabregas· 2 shared J. Sotolongo Bellon· 2 shared L. Wang· 2 shared M. Kazemian· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersImmunology

I. Moraga

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4 papers

Recent·Most cited

Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis

A. McFarlane, J. Sotolongo Bellon, T. Meyer, E. Pohler, J. Piehler, I. Moraga

The paper investigates how different JAKs in Gp130 signaling complexes lead to distinct STAT activation profiles and signaling outcomes.

bioRxiv · May 24, 2023 · PreprintCell Biology

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci

J. Martinez-Fabregas, L. Wang, E. Pohler, A. Cozzani, M. Kazemian, S. Mitra, I. Moraga

The paper identifies CDK8 as a negative regulator of STAT3 transcriptional activity in Th-1 cells, showing it limits STAT3's resident time at gene loci, thereby modulating IL-6 responses.

bioRxiv · Mar 19, 2020Immunology

Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses

C. Gorby, J. Sotolongo Bellon, S. Wilmes, W. Warda, E. Pohler, P. Fyfe, A. Cozzani, C. FERRAND, M. Walter, S. MITRA, J. Piehler, I. Moraga

This study engineered IL-10 variants with enhanced receptor affinity, showing improved bioactivity and gene expression at lower doses in human monocytes and CD8 T cells.

bioRxiv · Mar 10, 2020Immunology

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

J. Martinez-Fabregas, S. Wilmes, L. Wang, M. Hafer, E. Pohler, J. Lokau, C. Garbers, A. Cozzani, J. Piehler, M. Kazemian, S. Mitra, I. Moraga

The paper investigates how cytokine receptor binding kinetics affect signaling outcomes by engineering IL-6 variants with different affinities to gp130.

bioRxiv · May 16, 2019Immunology