Author

M. Kazemian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:statistical model· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3

Frequent Co-Authors

B. Yan· 6 shared L. Wang· 5 shared B. Afzali· 4 shared D. Chauss· 3 shared S. Mitra· 3 shared A. Cozzani· 2 shared A. Laurence· 2 shared C. Kemper· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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6 shared papersMicrobiology

B. Yan

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A comprehensive single cell data analysis of in lymphoblastoid cells reveals the role of Super-enhancers in maintaining EBV latency

B. Yan, C. Wang, S. Chakravorty, Z. Zhang, S. D. Kadadi, Y. Zhuang, I. Sirit, Y. Hu, M. Jung, S. Sahoo, L. Wang, K. Shao, N. L. Anderson, J. L. Trujillo-Ochoa, X. Liu, , M. Kazemian

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

bioRxiv · Aug 10, 2022Microbiology

RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancer

Z. Li, J. Sun, N. Rahman, B. Yan, S. Utturkar, N. A. Lanman, M. Kazemian, C. Caron de Fromentel, M. Levrero, O. Andrisani

This study shows that mTKIs like sorafenib downregulate DDX5, leading to activation of Wnt/β-catenin and non-canonical NF-κB pathways, which enable ferroptosis escape and mTKI resistance in liver cancer.

bioRxiv · Mar 31, 2022 · PreprintCancer Biology

Host-virus chimeric events in SARS-CoV2 infected cells are infrequent and artifactual

B. Yan, S. Chakravorty, C. Mirabelli, L. Wang, J. L. Trujillo-Ochoa, D. Chauss, D. Kumar, M. S. Lionakis, M. R. Olson, C. E. Wobus, B. Afzali, M. Kazemian

This study investigates host-virus chimeric (HVC) events in SARS-CoV2 RNA-seq data and finds they are rare and likely artifacts, not evidence of viral integration.

Journal of Virology · Jul 12, 2021Peer-reviewedMicrobiology

An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19

R. McGregor, D. Chauss, T. Freiwald, B. Yan, L. Wang, E. Nova-Lamperti, Z. Zhang, H. Teague, E. West, J. Bibby, A. Kelly, A. Malik, A. Freeman, D. Schwartz, D. Portilla, , B. Afzali

This study identifies a Vitamin D-driven mechanism that suppresses excessive Th1 responses in COVID-19, suggesting potential therapeutic use of Vitamin D analogs.

bioRxiv · Jul 18, 2020 · PreprintImmunology

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci

J. Martinez-Fabregas, L. Wang, E. Pohler, A. Cozzani, M. Kazemian, S. Mitra, I. Moraga

The paper identifies CDK8 as a negative regulator of STAT3 transcriptional activity in Th-1 cells, showing it limits STAT3's resident time at gene loci, thereby modulating IL-6 responses.

bioRxiv · Mar 19, 2020Immunology

RNF144A shapes the hierarchy of cytokine signaling to provide protective immunity against influenza

B. Afzali, S. Kim, E. West, E. Nova-Lamperti, N. Cheru, H. Nagashima, B. Yan, T. Freiwald, N. Merle, D. Chauss, M.-J. Bijlmakers, G. Wietsman, Z.-X. Yu, D. Jankovic, S. Mitra, , S. John

RNF144A regulates cytokine signaling hierarchy in T cells to enhance anti-influenza immunity by promoting STAT5 activation and limiting MAPK signaling.

bioRxiv · Sep 26, 2019 · PreprintImmunology

RNA Helicase DDX5 Negatively Regulates Wnt Signaling and Hepatocyte Reprogramming in Hepatitis B Virus-related Hepatocellular Carcinoma

S. K. Kailasam Mani, Z. Cui, B. Yan, S. Utturkar, A. Foca, N. Fares, D. Durantel, N. Lanman, P. Merle, M. Kazemian, O. Andrisani

This study identifies DDX5 as a negative regulator of Wnt signaling and hepatocyte reprogramming in HBV-related HCC, showing that restoring DDX5 levels suppresses Wnt activation and viral replication.

bioRxiv · Sep 12, 2019 · PreprintCancer Biology

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

J. Martinez-Fabregas, S. Wilmes, L. Wang, M. Hafer, E. Pohler, J. Lokau, C. Garbers, A. Cozzani, J. Piehler, M. Kazemian, S. Mitra, I. Moraga

The paper investigates how cytokine receptor binding kinetics affect signaling outcomes by engineering IL-6 variants with different affinities to gp130.

bioRxiv · May 16, 2019Immunology

PBRM1 regulates stress response in epithelial cells

E. G. Porter, A. Dhiman, B. Chowdhury, B. C. Carter, H. Lin, J. C. Stewart, M. Kazemian, M. K. Wendt, E. Dykhuizen

This study shows PBRM1 regulates stress response and apoptosis in epithelial cells by affecting reactive oxygen species and cell viability.

bioRxiv · Sep 4, 2018Cell Biology