Author

J. Martinez-Fabregas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Cozzani· 2 shared E. Pohler· 2 shared I. Moraga· 2 shared L. Wang· 2 shared M. Kazemian· 2 shared S. Mitra· 2 shared C. Garbers· 1 shared J. Lokau· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. Cozzani

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2 papers

Recent·Most cited

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci

J. Martinez-Fabregas, L. Wang, E. Pohler, A. Cozzani, M. Kazemian, S. Mitra, I. Moraga

The paper identifies CDK8 as a negative regulator of STAT3 transcriptional activity in Th-1 cells, showing it limits STAT3's resident time at gene loci, thereby modulating IL-6 responses.

bioRxiv · Mar 19, 2020Immunology

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

J. Martinez-Fabregas, S. Wilmes, L. Wang, M. Hafer, E. Pohler, J. Lokau, C. Garbers, A. Cozzani, J. Piehler, M. Kazemian, S. Mitra, I. Moraga

The paper investigates how cytokine receptor binding kinetics affect signaling outcomes by engineering IL-6 variants with different affinities to gp130.

bioRxiv · May 16, 2019Immunology