Structures of TGF-beta with betaglycan and the signaling receptors reveal the mechanism whereby betaglycan potentiates receptor complex assembly and signaling
L. Wieteska, A. B. Taylor, E. Punch, J. A. Coleman, I. O. Conway, Y.-F. Lin, C.-H. Byeon, C. S. Hinck, T. Krzysiak, R. Ishima, F. Lopez-Casillas, P. Cherepanov, D. J. Bernard, C. S. Hill, A. P. Hinck
This study determines the structure of TGF-beta bound to betaglycan and its signaling receptors, revealing mechanisms of ligand selectivity and signal potentiation.
bioRxiv · Jul 19, 2024 · PreprintBiophysics