A. P. Hinck

TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts

This paper shows TGM6, a helminth protein, mimics TGF-β binding to TβRII to inhibit TGF-β signaling in fibroblasts but not T cells.

The helminth TGF-beta mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-beta receptors to preferentially target myeloid cells

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.

Shear stress and very low levels of ligand synergize toactivate ALK1 signaling in endothelial cells

The paper investigates how shear stress and low ALK1 ligand levels synergize to activate ALK1 signaling in endothelial cells, revealing kinase activity and endocytosis as critical factors.

Computational modeling of TGF-β2:TβRI:TβRII receptor complex assembly as mediated by the TGF-β co-receptor betaglycan

The paper develops computational models to investigate how betaglycan enhances TGF-β2 signaling by facilitating receptor complex assembly.

Structure-based mapping of the TβRI and TβRII receptor binding sites of the parasitic TGF-β mimic, Hp-TGM

This paper identifies the receptor binding sites of the parasitic TGF-β mimic Hp-TGM using biophysical methods, showing it binds to TβRI and TβRII through specific domains.

Distinct autoinhibitory mechanisms regulate vinculin binding by alpha-T-catenin and alpha-E-catenin

This study identifies distinct autoinhibitory mechanisms in T-catenin and E-catenin regulating vinculin binding, showing that T-catenin's N-terminus maintains M-region autoinhibition.