Author

R. Ishima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

T. V. Ilina· 2 shared A. B. Taylor· 1 shared A. P. Hinck· 1 shared C. Adams· 1 shared C. Chen· 1 shared C. S. Hill· 1 shared C. S. Hinck· 1 shared C.-H. Byeon· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

T. V. Ilina

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structures of TGF-beta with betaglycan and the signaling receptors reveal the mechanism whereby betaglycan potentiates receptor complex assembly and signaling

L. Wieteska, A. B. Taylor, E. Punch, J. A. Coleman, I. O. Conway, Y.-F. Lin, C.-H. Byeon, C. S. Hinck, T. Krzysiak, R. Ishima, F. Lopez-Casillas, P. Cherepanov, D. J. Bernard, C. S. Hill, A. P. Hinck

This study determines the structure of TGF-beta bound to betaglycan and its signaling receptors, revealing mechanisms of ligand selectivity and signal potentiation.

bioRxiv · Jul 19, 2024 · PreprintBiophysics

Discovery of a novel human antibody VH domain with potent activity against mesothelin expressing cancer cells in both CAR T-cell and antibody drug conjugate formats

Z. Sun, X. Chu, C. Adams, T. V. Ilina, C. Chen, D. Jelev, R. Ishima, W. Li, J. W. Mellors, G. Calero, D. S. Dimitrov

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

bioRxiv · Apr 7, 2022 · PreprintCancer Biology

An inhibitor-interaction intermediate of HIV-1 protease, revealed by Isothermal Titration Calorimetry and NMR spectroscopy

S. N. Khan, J. D. Persons, M. Guerrero, T. V. Ilina, M. Oda, R. Ishima

The paper investigates entropy-enthalpy compensation in HIV-1 protease mutants using ITC and NMR, revealing an inhibitor-bound intermediate pathway.

bioRxiv · Sep 4, 2018 · PreprintBiochemistry