Author

E. Pursey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

E. Westra· 3 shared S. van Houte· 3 shared S. Gandon· 2 shared A. Chevallereau· 1 shared A. Daraba· 1 shared A. Dunai· 1 shared A. Grasso· 1 shared A. Lujan· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersEvolutionary Biology

E. Westra

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Antibiotics of the future are prone to resistance in Gram-negative pathogens

L. Daruka, M. S. Czikkely, P. Szili, Z. Farkas, D. Balogh, G. Grezal, E. Maharramov, T.-H. Vu, L. Sipos, S. Juhasz, A. Dunai, A. Daraba, M. Szamel, T. Sari, T. Stirling, , C. Pal

This study shows new antibiotics are as likely to face resistance as existing ones in Gram-negative bacteria, highlighting the need for narrow-spectrum therapies.

bioRxiv · Jul 23, 2023Microbiology

Eco-evolutionary feedbacks shape the evolution of constitutive and inducible defences

B. Watson, E. Pursey, S. Gandon, E. Westra

The paper shows that the initial resistance mechanism in bacteria during an epidemic strongly influences the evolution of constitutive and inducible defenses, with ecological factors shaping long-term outcomes.

bioRxiv · Apr 14, 2023 · PreprintEvolutionary Biology

Bacterial defences interact synergistically by disrupting phage cooperation

A. Maestri, E. Pursey, C. Chong, B. J. Pons, S. Gandon, R. Custodio, M. Chisnall, A. Grasso, S. Paterson, K. S. Baker, S. van Houte, A. Chevallereau, E. Westra

This study identifies a novel bacterial defence system, MADS, which synergizes with CRISPR-Cas to protect against phages with anti-CRISPR genes by disrupting phage cooperation.

bioRxiv · Mar 30, 2023 · PreprintMicrobiology

CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens

E. Pursey, T. Dimitriu, F. L. Paganelli, E. R. Westra, S. van Houte

The paper analyzes bacterial genomes to show that CRISPR-Cas systems are associated with fewer antibiotic resistance genes, suggesting they limit horizontal gene transfer of resistance.

bioRxiv · Apr 12, 2021Microbiology

Bacterial biodiversity drives the evolution of CRISPR-based phage resistance in Pseudomonas aeruginosa

E. O. Alseth, E. Pursey, A. Lujan, I. McLeod, C. Rollie, E. Westra

This study shows that bacterial biodiversity promotes CRISPR-based phage resistance evolution in Pseudomonas aeruginosa by increasing fitness trade-offs associated with receptor mutation.

bioRxiv · Mar 24, 2019Evolutionary Biology