S. Paterson

Superiority of chromosomal compared to plasmid-encoded compensatory mutations

This study compares the ecological effects of compensatory mutations on plasmids and chromosomes, finding that chromosomal mutations are more effective in reducing plasmid fitness costs and promoting plasmid spread.

Bacterial defences interact synergistically by disrupting phage cooperation

This study identifies a novel bacterial defence system, MADS, which synergizes with CRISPR-Cas to protect against phages with anti-CRISPR genes by disrupting phage cooperation.

The Ecology of Viruses in Urban Rodents with a Focus on SARS-CoV-2

The study investigates viral ecology in urban rodents during the COVID-19 pandemic, finding no SARS-CoV-2 infection but evidence of potential exposure through antibodies.

Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection and reproduction in a wild rodent

This study identifies a sex-dependent polymorphism in the IgE receptor affecting immune gene expression, infection susceptibility, and reproductive success in wild field voles.

Early-life immune expression profiles predict later life health and fitness in a wild rodent

The paper examines how early-life immune gene expression profiles in voles predict later life health and fitness outcomes, including reproductive success and infection susceptibility.

Assessment of CAR-T mediated and targeted cytotoxicity in 3D microfluidic TBNC co-culture models for combination therapy

This study evaluates CAR-T cytotoxicity in 3D microfluidic models of triple-negative breast cancer, showing enhanced efficacy with combination therapy.

Plasmid fitness costs are caused by specific genetic conflicts

The paper identifies specific genetic conflicts as the cause of plasmid fitness costs in Pseudomonas fluorescens, showing that single mutations can ameliorate these costs.

Quantifying multivariate genotype-by-environment interactions, evolutionary potential and its context-dependence in natural populations of the water flea, Daphnia magna.

The paper quantifies multivariate genotype-by-environment interactions in Daphnia magna and finds context-dependent evolutionary potential for food vs. temperature responses.

Genome-wide changes in genetic diversity in a population of Myotis lucifugus affected by white-nose syndrome

The paper uses whole-genome sequencing to analyze genetic diversity changes in Myotis lucifugus before and after white-nose syndrome, finding increased divergence in a specific genomic region associated with thermoregulation.

Spatial heterogeneity of an ecologically relevant environment accelerates diversification and adaptation.

The paper shows that spatial heterogeneity in soil compost promotes phenotypic diversification and accelerates adaptation in Pseudomonas fluorescens.

The genomic basis of evolved virus resistance is dependent on environmental resources

This study identifies genomic mechanisms of virus resistance in a lepidopteran pest, showing that resistance evolves differently under varying nutritional conditions and is linked to metabolic, immune, or cytoskeleton pathways.

Decomposing variation in immune response in a wild rodent population

The paper identifies three categories of immune response variation in field voles and finds markers with strong individual variation across these categories.

Transposable temperate phages promote the evolution of divergent social strategies in Pseudomonas aeruginosa populations

This study shows transposable phages drive divergence in social strategies of Pseudomonas aeruginosa by promoting extreme siderophore production phenotypes in iron-limited environments.