Author

K. S. Baker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:whole-genome sequencing· 6 Research Focus:host-pathogen & immune response· 5 Organism:bacteria (other)· 4 Research Focus:variant calling· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

C. Jenkins· 4 shared C. V. Pulford· 4 shared N. Hall· 3 shared R. J. Bengtsson· 3 shared J. C. D. Hinton· 2 shared K. E. Holt· 2 shared P. M. De Silva· 2 shared R. Low· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMicrobiology

C. Jenkins

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Bacterial defences interact synergistically by disrupting phage cooperation

A. Maestri, E. Pursey, C. Chong, B. J. Pons, S. Gandon, R. Custodio, M. Chisnall, A. Grasso, S. Paterson, K. S. Baker, S. van Houte, A. Chevallereau, E. Westra

This study identifies a novel bacterial defence system, MADS, which synergizes with CRISPR-Cas to protect against phages with anti-CRISPR genes by disrupting phage cooperation.

bioRxiv · Mar 30, 2023 · PreprintMicrobiology

Shigella serotypes associated with carriage in humans establish persistent infection in zebrafish

V. Torraca, D. Brokatzky, S. L. Miles, C. E. Chong, P. M. De Silva, S. Baker, C. Jenkins, K. E. Holt, K. S. Baker, S. Mostowy

This paper shows that three Shigella serotypes associated with MSM transmission can establish persistent infection in zebrafish, failing to promote macrophage cell death.

bioRxiv · Nov 8, 2022 · PreprintMicrobiology

Sequence-dependent mechanochemical coupling of helicase translocation and unwinding at single-nucleotide resolution.

A. H. Laszlo, J. M. Craig, M. Gavrilov, R. Tippana, I. C. Nova, J. R. Huang, H. C. Kim, S. J. Abell, M. deCampos-Stairiker, J. W. Mount, J. L. Bowman, K. S. Baker, H. Higinbotham, D. Bobrovnikov, T. Ha, J. H. Gundlach

This study uses SPRNT to analyze how DNA sequence affects PcrA helicase kinetics during translocation and unwinding at single-nucleotide resolution.

bioRxiv · Feb 10, 2022Biophysics

An accessible, efficient and global approach for the large-scale sequencing of bacterial genomes

B. M. Perez-Sepulveda, D. Heavens, C. V. Pulford, A. V. Predeus, R. Low, H. Webster, C. Schudoma, W. Rowe, J. Lipscombe, C. Watkins, B. Kumwenda, N. Shearer, K. Costigan, K. S. Baker, N. A. Feasey, , The 10KSG consortium

The paper describes a low-cost, efficient pipeline for large-scale bacterial genome sequencing, demonstrating its application in collecting and sequencing 10,419 isolates from multiple countries.

Genome Biology · Dec 21, 2021Peer-reviewedMicrobiology

A tale of two plasmids: contributions of plasmid associated phenotypes to epidemiological success among Shigella

P. M. De Silva, G. E. Stenhouse, G. E. Blackwell, R. Bengtsson, C. Jenkins, J. P. J. Hall, K. S. Baker

This study compares two Shigella plasmids to identify plasmid features contributing to differences in their epidemiological success during outbreaks.

bioRxiv · Dec 17, 2021Microbiology

Informing shigellosis prevention and control through pathogen genomics

R. J. Bengtsson, A. J. Simpkin, C. V. Pulford, R. Low, D. A. Rasko, D. J. Rigden, N. Hall, E. M. Barry, S. M. Tennant, K. S. Baker

This study uses genomic analysis of Shigella strains from seven LMIC to show S. sonnei's high disease contribution and convergent antimicrobial resistance evolution, highlighting the need for updated vaccine and treatment strategies.

bioRxiv · Jun 9, 2021 · PreprintMicrobiology

Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei

J. Hawkey, K. Paranagama, K. S. Baker, R. J. Bengtsson, F.-X. Weill, N. R. Thomson, S. Baker, L. Cerdeira, Z. Iqbal, M. Hunt, D. J. Ingle, T. J. Dallman, C. Jenkins, D. A. Williamson, K. E. Holt

The paper develops a genomic framework and genotyping scheme for Shigella sonnei to identify resistance determinants from WGS data, revealing common genotypes linked to antimicrobial resistance and global spread.

bioRxiv · Oct 29, 2020Microbiology

Accessory genome dynamics and structural variation of Shigella from persistent infections

R. J. Bengtsson, T. J. Dallman, C. Jenkins, H. Allen, M. D. Silva, G. Stenhouse, C. V. Pulford, R. J. Bennett, K. S. Baker

This study examines accessory genome dynamics and structural variations in Shigella isolates from persistent infections in men who have sex with men, finding less variation in persistent carriage compared to reinfection and evidence of antimicrobial resistance acquisition.

bioRxiv · Sep 28, 2020Microbiology

The diversity, evolution and ecology of Salmonella in venomous snakes

C. V. Pulford, N. Wenner, M. L. Redway, E. V. Rodwell, H. J. Webster, R. Escudero, C. Kröger, R. Canals, W. Rowe, J. Lopez, N. Hall, P. D. Rowley, D. Timofte, R. A. Harrison, K. S. Baker, J. C. D. Hinton

This study investigates Salmonella diversity in venomous snakes, finding 91% prevalence and identifying metabolic differences between subspecies, suggesting a potential role in human Salmonellosis in Africa.

bioRxiv · Jan 21, 2019Microbiology