Structural basis of nirmatrelvir and ensitrelvir resistance profiles against SARS-CoV-2 Main Protease naturally occurring polymorphisms
G. D. Noske, E. S. Silva, M. O. Godoy, I. Dolci, R. S. Fernandes, R. V. C. Guido, P. Sjo, G. Oliva, A. S. Godoy
The paper characterizes natural polymorphisms in SARS-CoV-2 main protease and their resistance profiles against nirmatrelvir and ensitrelvir, revealing structural bases for resistance.
bioRxiv · Aug 31, 2022 · PreprintBiochemistry