Author

R. S. Fernandes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

G. Oliva· 3 shared A. C. Puhl· 2 shared A. S. Godoy· 2 shared G. D. Noske· 2 shared S. Ekins· 2 shared A. M. Nakamura· 1 shared A. S. de Godoy· 1 shared A. T. Fabro· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

G. Oliva

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis of nirmatrelvir and ensitrelvir resistance profiles against SARS-CoV-2 Main Protease naturally occurring polymorphisms

G. D. Noske, E. S. Silva, M. O. Godoy, I. Dolci, R. S. Fernandes, R. V. C. Guido, P. Sjo, G. Oliva, A. S. Godoy

The paper characterizes natural polymorphisms in SARS-CoV-2 main protease and their resistance profiles against nirmatrelvir and ensitrelvir, revealing structural bases for resistance.

bioRxiv · Aug 31, 2022 · PreprintBiochemistry

Discovery of a Novel Inhibitor for Chikungunya Virus

A. C. Puhl, R. S. Fernandes, A. S. Godoy, L. H. V. G. Gil, G. Oliva, S. Ekins

This study identifies 3-methyltoxoflavin as an inhibitor of Chikungunya virus with EC50 200 nM and activity against yellow fever virus.

bioRxiv · Mar 23, 2022 · PreprintMicrobiology

Pyronaridine Protects Against SARS-CoV-2 in Mouse

A. C. Puhl, G. F. Gomes, S. Damasceno, A. S. de Godoy, G. D. Noske, A. M. Nakamura, V. O. Gawrijuk, R. S. Fernandes, N. Monakhova, O. Riabova, T. R. Lane, V. Makarov, F. P. Veras, S. S. Batah, A. T. Fabro, , S. Ekins

Pyronaridine reduces SARS-CoV-2 viral load and lung pathology in mice, with in vitro inhibition of viral PLpro and host kinase CAMK1.

bioRxiv · Sep 30, 2021 · PreprintPharmacology & Toxicology