W. Xie

Histone marks enable formation of immiscible phase-separated chromatin compartments

The paper shows that histone marks drive phase-separated chromatin compartments, influencing gene expression and cancer progression through the CBX7-PRC1 complex.

Super-Enhancer Driven ZFP36L1 Promotes PD-L1 Expression in Infiltrative Gastric Cancer

This study identifies ZFP36L1, driven by a super-enhancer, as a key regulator of PD-L1 expression in infiltrative gastric cancer, contributing to immune escape.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF

The paper identifies resting NK cells that promote colon cancer liver metastasis by enhancing tumor-derived sSCF through cell-to-cell interactions.

Environmental DNA from ethanol eluent of flowers reveals a widespread diversity in cowpea associated animal communities in Hainan Island

This study uses eDNA metabarcoding to analyze cowpea-associated animal communities in Hainan, identifying 62 species, mostly arthropods, and highlighting regional diversity and pesticide impacts.

Grayscale 4D Biomaterial Customization at High Resolution and Scale

This paper introduces GIZMO, a method to create 3D grayscale hydrogel patterns for more realistic tissue engineering.

Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice

This study shows that deleting Glyoxalase 1 worsens acetaminophen-induced liver damage in mice by increasing oxidative stress and necrosis.

Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization

This study identifies beta2-adrenergic signaling as a key driver of bone healing by enhancing callus neovascularization, with implications for therapeutic strategies and the risks of beta-blockers.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

Gene inversion triggered origination of brackish archaeal heterotrophs in the aftermath of the Cryogenian Snowball Earth

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

Distinct Single-cell Immune Ecosystems Distinguish True and De Novo HBV-related Hepatocellular Carcinoma Recurrences

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

Barley powdery mildew effector CSEP0162 targets multivesicular body-associated MON1 important for immunity

The paper identifies CSEP0162 as a barley powdery mildew effector that targets MON1, inhibiting encasement formation and HR, highlighting MON1's role in plant immunity.

Powdery mildew effectors AVRA1 and BEC1016 target the ER J-domain protein HvERdj3B required for immunity in barley

A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development

This paper develops a chimpanzee adenovirus-based vaccine against the SARS-CoV-2 Delta variant and shows it induces strong immunity and protects mice from challenge.

Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in C. elegans

This paper shows that oxidative stress causes age-related muscle dysfunction in C. elegans by oxidizing the RyR homolog UNC-68 and reducing its stabilizing subunit FKB-2, leading to calcium leaks and muscle weakness.

Olfactory host entry supports herpesvirus recombination

The paper shows that olfactory entry enables herpesvirus recombination between co-infecting strains, unlike lung infection.

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

Single-molecule mechanical unfolding kinetics of unmodified Saccharomyces cerevisiae tRNAPhe: a hint to the tRNA chaperone-tRNA interaction mechanism

This study uses optical tweezers and molecular dynamics to analyze the mechanical unfolding kinetics of yeast tRNAphe, revealing how structural features influence folding and the role of tertiary interactions in unfolding cooperativity.

Class II LBD genes ZmLBD5 and ZmLBD33 regulate gibberellin and abscisic acid biosynthesis

This study identifies ZmLBD5 and ZmLBD33 as class II LBD genes in maize that regulate gibberellin and abscisic acid biosynthesis, affecting plant growth and drought tolerance.

Polycomb repressive complex 2 coordinates with Sin3 histone deacetylase complex to epigenetically reprogram genome-wide expression of effectors and regulate pathogenicity in Magnaporthe oryzae

The paper shows that Polycomb repressive complex 2 and Sin3 histone deacetylase complex work together to epigenetically control effector gene expression in Magnaporthe oryzae, regulating its pathogenicity.

Thinopyrum intermedium TiAP1 interacts with a chitin deacetylase from Blumeria graminis f. sp. tritici and increases the resistance to Bgt in wheat

This study identifies TiAP1 from Thinopyrum intermedium as a resistance gene against Blumeria graminis f. sp. tritici, showing it interacts with BgtCDA1 and enhances wheat resistance through immune activation.

Spatiotemporal Dynamics of Intra-tumoral Dependence on NEK2-EZH2 Signaling in Glioblastoma Cancer Progression

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

The essential transcriptional regulator HDP1 drives expansion of the inner membrane complex during early sexual differentiation of malaria parasites.

This study identifies HDP1 as a transcriptional regulator essential for upregulating inner membrane complex genes during early gametocytogenesis in Plasmodium falciparum.

Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells

This study shows that intestinal microbiota modulates epinephrine storage and secretion in adrenal chromaffin cells via Nod1 sensing of bacterial ligands during stress.

Asprosin Neutralizing Antibodies as a Treatment for Metabolic Syndrome

This paper shows anti-asprosin monoclonal antibodies reduce appetite, body weight, and blood glucose in metabolic syndrome mouse models.

SARS-Cov-2-, HIV-1-, Ebola-neutralizing and anti-PD1 clones are predisposed

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

Integrative Molecular Characterization of Sarcomatoid and Rhabdoid Renal Cell Carcinoma Reveals Determinants of Poor Prognosis and Response to Immune Checkpoint Inhibitors

This study characterizes the molecular features and immune profile of sarcomatoid and rhabdoid renal cell carcinoma, showing their responsiveness to immune checkpoint inhibitors and identifying key genetic and transcriptional determinants.

Multiplexed in situ protein imaging using DNA-barcoded antibodies withextended hybridization chain reactions

This paper introduces a DNA-based method to enhance multiplexed protein imaging using primary antibodies, demonstrating its application in cultured cells and mouse retina sections.

FalseColor-Python: a rapid intensity-leveling and digital-staining package for fluorescence-based slide-free digital pathology

FalseColor-Python converts grayscale fluorescence images to H&E-like color images, offering automated, uniform false coloring and GPU acceleration for 2D/3D microscopy datasets.

Proteasome activator PA200 maintains stability of histone marks during transcription and aging

This study shows that PA200 maintains histone mark stability during transcription and aging by promoting acetylation-dependent degradation of core histones.