Author

R. Sundaramoorthy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. Ciulli· 1 shared A. Correa-Saez· 1 shared A. D. Cowan· 1 shared A. Rukavina· 1 shared A. Testa· 1 shared C. Craigon· 1 shared C. Maniaci· 1 shared C. Schatz· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. Ciulli

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Joint effects of balancing selection and population bottlenecks on the evolution of a regulatory region of human anti-viral APOBEC3

N. T. Fujito, R. Sundaramoorthy, Y. Satta, I. Inoue

The paper investigates how balancing selection and population bottlenecks shape genetic diversity in a human APOBEC3 regulatory region, identifying haplogroups and evolutionary mechanisms.

bioRxiv · Jul 18, 2023Evolutionary Biology

Targeted protein degradation via intramolecular bivalent glues

O. Hsia, M. Hinterndorfer, A. D. Cowan, K. Iso, T. Ishida, R. Sundaramoorthy, M. A. Nakasone, H. Imrichova, C. Schatz, A. Rukavina, K. Husnjak, M. Wegner, A. Correa-Saez, C. Craigon, R. Casement, , A. Ciulli

This paper introduces intramolecular bivalent glues (IBGs) as a new method for targeted protein degradation, showing they enhance ubiquitination by bridging protein domains and improving degradation efficiency.

bioRxiv · Feb 14, 2023Biochemistry

Structure and mechanism of the type I-G CRISPR effector

Q. Shangguan, S. Graham, R. Sundaramoorthy, M. F. White

This study reports the structure and function of the type I-G CRISPR effector from Thioalkalivibrio sulfidiphilus, revealing key molecular details about its composition and mechanism.

bioRxiv · Aug 8, 2022Microbiology

Non canonical scaffold-type ligase complex mediates protein UFMylation

J. J. Peter, H. M. Magnussen, P. A. DaRosa, D. Millrine, S. P. Matthews, F. Lamoliatte, R. Sundaramoorthy, R. R. Kopito, Y. Kulathu

The paper identifies the minimal requirements for protein UFMylation and reveals the regulatory mechanism of an atypical scaffold-type E3 ligase complex.

bioRxiv · Jan 31, 2022 · PreprintBiochemistry