Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range
D. Ni, P. Turelli, B. Beckert, S. Nazarov, E. Uchikawa, A. Myasnikov, F. Pojer, D. Trono, H. Stahlberg, K. Lau
The paper reports cryo-EM structures of mouse ACE2 bound to SARS-CoV-2 VOC Spike proteins, showing mutations enabling immune escape may expand host range.
bioRxiv · Aug 19, 2022Immunology