Author

K. N. Parent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

J. R. Schrad· 3 shared J. A. Dover· 2 shared S. Subramanian· 2 shared A. Alexandrescu· 1 shared A. J. Wessel· 1 shared B. J. Ridenhour· 1 shared B. Y. Hsueh· 1 shared C. A. Elg· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

J. R. Schrad

Mutual co-authors in cluster

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6 papers

Recent·Most cited

A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

C. M. Boyd, S. Subramanian, D. T. Dunham, K. N. Parent, K. D. Seed

This study identifies TcaP as a protein that remodels phage ICP1 capsids into smaller structures, enhancing PLE satellite transduction and inhibiting ICP1.

bioRxiv · Mar 1, 2023 · PreprintMicrobiology

Host range expansion of Shigella phage Sf6 evolves through the dual roles of its tailspike

S. Subramanian, J. A. Dover, K. N. Parent, S. M. Doore

This paper shows that phage Sf6 evolves to expand its host range by mutating its tailspike protein to overcome inhibitory LPS interactions with serotype 2a2.

bioRxiv · Apr 6, 2022 · PreprintMicrobiology

A Broadly Conserved Deoxycytidine Deaminase Protects Bacteria from Phage Infection

G. B. Severin, B. Y. Hsueh, C. A. Elg, J. A. Dover, C. R. Rhoades, A. J. Wessel, B. J. Ridenhour, E. M. Top, J. Ravi, K. N. Parent, C. M. Waters

The study identifies DcdV, a deoxycytidine deaminase in V. cholerae, as a novel phage defense mechanism conserved across bacteria and eukaryotes.

bioRxiv · Mar 31, 2021 · PreprintMicrobiology

The Mitochondrial Permeability Transition Phenomenon Elucidated by Cryo-EM Reveals the Genuine Impact of Calcium Overload on Mitochondrial Structure and Function

J. O. Strubbe, J. R. Schrad, E. V. Pavlov, J. F. Conway, K. N. Parent, J. N. Bazil

The study uses cryo-EM to show how calcium overload causes mitochondrial permeability transition by forming calcium phosphate granules and inner membrane fragmentation, and reveals cyclosporin A's role in preserving inner membrane structure.

Scientific Reports · Jan 13, 2021Peer-reviewedCell Biology

Boiling Acid Mimics Intracellular Giant Virus Genome Release

J. R. Schrad, J. S. Abrahao, J. R. Cortines, K. N. Parent

This study identifies conserved molecular forces triggering giant virus genome release and identifies specific proteins released during infection.

bioRxiv · Sep 20, 2019 · PreprintBiophysics

The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy

R. L. Newcomer, J. R. Schrad, E. B. Gilcrease, S. R. Casjens, M. Feig, C. M. Teschke, A. Alexandrescu, K. N. Parent

The paper determines the structure of the phage L Dec protein and its binding strategy to the capsid using cryo-EM and NMR.

bioRxiv · Feb 1, 2019Biophysics