Author

J. F. Conway

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2 Biophysics· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 4 Assay:structural biology· 3 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Organism:virus· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Huet· 4 shared A. A. Antson· 1 shared A. A. Bridges· 1 shared A. Arun· 1 shared A. K. Belford· 1 shared A. M. Makhov· 1 shared B. E. Smith· 1 shared C. G. Baumann· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersBiochemistry

A. Huet

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Structures of kinetic intermediate states of HIV-1 reverse transcriptase DNA synthesis

S. Vergara, X. Zhou, U. Santiago, J. F. Conway, N. Sluis-Cremer, G. Calero

This study captures 11 structures of HIV-1 reverse transcriptase during DNA synthesis, revealing intermediate states and mechanisms of dATP incorporation and drug resistance.

bioRxiv · Dec 18, 2023 · PreprintBiophysics

Pneumococcal Extracellular Vesicles Mediate Horizontal Gene Transfer via the Transformation Machinery

S. Werner Lass, S. Camphire, B. E. Smith, R. A. Smith, J. A. Prentice, S. S. Yerneni, A. Arun, A. A. Bridges, J. W. Rosch, J. F. Conway, P. Campbell, N. L. Hiller

This paper shows pneumococcal extracellular vesicles carry DNA that can be transferred to competent cells via the transformation machinery, promoting horizontal gene transfer and potential antibiotic resistance spread.

bioRxiv · Dec 15, 2023 · PreprintMicrobiology

A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability

J. M. Podgorski, K. Freeman, S. Gosselin, A. Huet, J. F. Conway, M. Bird, J. Grecco, S. Patel, D. Jacobs-Sera, G. Hatfull, J. P. Gogarten, J. Ravantti, S. J. White

The paper constructs a structural dendrogram of actinobacteriophage major capsid proteins to explore the evolution of capsid stability using cryo-EM, phylogenetic analysis, and AlphaFold predictions.

bioRxiv · Sep 9, 2022Biochemistry

Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system

H. K. H. Fung, S. Grimes, A. Huet, R. L. Duda, M. Chechik, J. Gault, C. V. Robinson, R. W. Hendrix, P. J. Jardine, J. F. Conway, C. G. Baumann, A. A. Antson

This study describes the structural and biochemical mechanisms of DNA packaging by the HK97 bacteriophage's terminase complex, revealing similarities to other viral systems.

bioRxiv · May 10, 2022Biochemistry

Lipidoid nanoparticles increase ATP uptake into hypoxic brain endothelial cells

P. Khare, J. F. Conway, D. Soundara Manickam

This paper demonstrates that lipidoid nanoparticles (LNPs) can deliver ATP to brain endothelial cells, increasing ATP uptake under both normoxic and hypoxic conditions.

bioRxiv · Apr 7, 2022Bioengineering

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes

D. Sun, Z. Sang, J. Kim, Y. Xiang, T. Cohen, A. K. Belford, A. Huet, J. F. Conway, J. Sun, D. Taylor, C. Zhang, W. Huang, Y. Shi

bioRxiv · Mar 9, 2021Biophysics

The Mitochondrial Permeability Transition Phenomenon Elucidated by Cryo-EM Reveals the Genuine Impact of Calcium Overload on Mitochondrial Structure and Function

J. O. Strubbe, J. R. Schrad, E. V. Pavlov, J. F. Conway, K. N. Parent, J. N. Bazil

The study uses cryo-EM to show how calcium overload causes mitochondrial permeability transition by forming calcium phosphate granules and inner membrane fragmentation, and reveals cyclosporin A's role in preserving inner membrane structure.

Scientific Reports · Jan 13, 2021Peer-reviewedCell Biology

Mechanisms of antibody binding revealed by asymmetric Fab-virus complexes

D. J. Goetschius, S. R. Hartmann, L. J. Organtini, H. Callaway, K. Huang, C. M. Bator, R. E. Ashley, A. M. Makhov, J. F. Conway, C. R. Parrish, S. L. Hafenstein

The paper uses cryo-EM to analyze antibody binding to parvovirus capsids, revealing structural insights into epitope-receptor interactions and species-specific neutralization.

bioRxiv · Dec 1, 2020 · PreprintMicrobiology

The apical region of the herpes simplex virus major capsid protein promotes capsid maturation

L. L. Ruhge, A. Huet, J. F. Conway, G. A. Smith

This study investigates the role of the VP5 apical region in herpes simplex virus capsid maturation and finds that mutations in this region delay viral propagation and induce procapsid accumulations.

bioRxiv · May 11, 2018Microbiology