Metabolism-dependent secondary effect of anti-MAPK cancer therapy on DNA repair
F. Aube, N. Fontrodona, L. Guiguettaz, E. Vallin, A. Lapendry, E. P. Ricci, D. Auboeuf
This study shows that MAPK inhibitors reduce aspartate and glutamate in melanoma cells, leading to DNA repair defects and increased mutations through metabolic adaptation.
bioRxiv · Jun 19, 2023Cancer Biology