F. Picard

In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection

The paper uses in silico analysis of single-cell RNA-seq data to identify a new metabolic transition stage in CD8 T cells 4 days post-infection.

Pentose Phosphate Pathway Inhibition activates Macrophages towards phagocytic Lymphoma Cell Clearance

This study shows that inhibiting the pentose phosphate pathway enhances macrophage phagocytosis of lymphoma cells and improves survival in a mouse model.

Differentiation is accompanied by a progressive loss in transcriptional memory

The paper quantifies how transcriptional memory decreases during differentiation by comparing related and unrelated cells across generations.

Evidence for close molecular proximity between reverting and undifferentiated cells

The paper characterizes reverting cells by comparing their molecular state to undifferentiated cells using single-cell transcriptomic data and finds they return to an earlier molecular state with minimal differences.

Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine

This study designs a pan-sarbecovirus vaccine targeting conserved epitopes and shows it induces cross-neutralizing antibodies and T-cell responses in mice and humans.

A derived ZW chromosome system in Amborella trichopoda, the sister species to all other extant flowering plants

The paper identifies a ZW sex chromosome system in Amborella trichopoda, revealing a 4 Mb sex-determining region on chromosome 9 with recent divergence.

T cells are present in non-diabetic islets and accumulate during aging.

The paper shows T cells are present in non-diabetic islets and increase with age in mice and humans, independent of body weight.

The wild grape genome sequence provides insights into the transition from dioecy to hermaphroditism during grape domestication

This study sequenced the wild grape genome to understand the genetic transition from dioecy to hermaphroditism during grape domestication.

Clonally distinct differentiation trajectories shape CD8+ memory T cell heterogeneity after acute viral infections in humans

The paper tracks CD8+ T cell clones after yellow fever vaccination, showing clonal selection and biased differentiation trajectories shaping memory T cell heterogeneity.

Evolution of Replication Origins in Vertebrate Genomes: Rapid Turnover Despite Selective Constraints.

The paper compares replication origin maps across vertebrates to study their evolutionary dynamics and functional constraints, finding rapid turnover despite some genetic constraints.

Genomic imprinting mediates dosage compensation in a young plant XY system

The paper identifies genomic imprinting as a dosage compensation mechanism in the young XY system of Silene latifolia, compensating for reduced Y gene expression in males.