Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas
A. L. H. Webster, M. A. Sanders, K. Patel, R. Dietrich, R. J. Noonan, F. P. Lach, R. R. White, A. Goldfarb, K. Hadi, M. M. Edwards, F. X. Donovan, M. Jung, S. Sridhar, O. Fedrigo, H. Tian, , P. Campbell
This paper shows that FA pathway deficiency in squamous cell carcinomas leads to high structural variant rates and copy number alterations, linking genomic instability to tumor progression.
bioRxiv · Aug 14, 2021 · PreprintCancer Biology