USP15: the fourth Proteasome-associated DUB
Shahar Levi, Fabian Glaser, Ajay R. Wagh, Eden Filimonov, Noa Reis, Sachin Mali, Sumeet K. Singh, Noam Cohen, Insuk Byun, Min Jae Lee, Oded Kleifeld, Ashraf Brik, Michael H. Glickman, Indrajit Sahu
The paper identifies USP15 as a fourth proteasome-associated DUB, showing it binds transiently to proteasomes and selectively disassembles short polyubiquitin chains.
bioRxiv · Aug 13, 2025 · PreprintBiochemistry