Hypoxia-induced mitoROS triggers M1 linear ubiquitin chains and activates NF-κB signaling
Kiri Tal, Jonathan Ram, Noa Reis, Inbal Maniv, Ordureau Alban, Michael H. Glickman, Prasad Sulkshane
The paper shows hypoxia-induced mitochondrial ROS leads to M1 ubiquitin chains, activating NF-κB signaling and increasing target gene expression in response to mitochondrial stress.
bioRxiv · Nov 6, 2025 · PreprintBiochemistry