Michael H. Glickman

This study identifies p62 as a key mediator of UBB+1 secretion via autophagy, revealing a dual role for autophagy in managing neurotoxic proteins.

The paper shows hypoxia-induced mitochondrial ROS leads to M1 ubiquitin chains, activating NF-κB signaling and increasing target gene expression in response to mitochondrial stress.

The paper identifies USP15 as a fourth proteasome-associated DUB, showing it binds transiently to proteasomes and selectively disassembles short polyubiquitin chains.