RIPK1 regulates beta-cell fate via actions on gene expression and kinase signaling in a mouse model of beta-cell self-reactivity
Christopher Contreras, Noyonika Mukherjee, Arianna Harris-Kawano, Egan G. Mather, Nansalmaa Amarsaikhan, Christopher M. Davis, Christine A. Berryhill, Madeline Peyton, Debjyoti Kundu, Kaitlyn A. Colglazier, Addison S. Miller, Renato Chaves Souto Branco, Travis S. Johnson, Steven P. Angus, Sylvaine You, , Andrew T. Templin
This study shows RIPK1 promotes beta-cell death in autoimmune diabetes by affecting gene expression and kinase signaling, suggesting it as a therapeutic target.
Cell Death and Disease · Feb 12, 2026Peer-reviewedCell Biology